Author
Fariba Behnia-Willison,Sara Sarraf Joseph Miller,Joseph Miller,Joseph Miller,Behrang,Mohamadi,Alison Care,Alan Lam,Nadia Willison,Leila Behnia,Stefano Salvatore

Abstract

Objectives
To evaluate the safety and long-term efficacy of fractional CO2 laser treatment in reducing the severity of symptoms of genitourinary syndrome of menopause (GSM) in menopausal women.

Study design
102 women presenting with symptomatic GSM were treated with the fractional CO2 laser (MonaLisa Touch, DEKA) system across a series of treatments delivered at intervals of six or more weeks. The Australian Pelvic Floor Questionnaire was used to gather data on sexual function and side-effects at three time-points across the study period (prospective panel design study). Wilcoxon signed-rank tests were used to detect statistically and clinically significant changes in sexual function and side-effects occurring from pre- to post-treatment. The primary outcome of this study was an improvement of the symptoms of GSM. The secondary outcome included bladder function and prolapse symptoms.

Results
A total of 102 women suffering from moderate to severe GSM were recruited. Eighty-four percent experienced significant improvement in their symptoms after CO2 laser treatment. Scores on measures of sexual function, dyspareunia, and bothersomeness of sexual issues were improved from pre-treatment to long-term (12–24 month) follow-up. Furthermore, there were improvements on measures of bladder function (P = 0.001), prolapse (P = 0.001), vaginal sensation (P = 0.001), vaginal lubrication (P < 0.001) and urge incontinence (P = 0.003) from the pre-treatment assessment to the second assessment (i.e. after the third treatment).

Conclusions
In this study, fractional microablative CO2 laser treatment was associated with an improvement in symptoms of GSM and sexual function.

資料來源：European Journal of Obstetrics and Gynecology