Breast. 2016 Oct 27;31:16-19. doi: 10.1016/j.breast.2016.10.018. [Epub ahead of print]

 

Bošković L¹, Gašparić M², Petković M³, Gugić D⁴, Lovasić IB⁵, Soldić Ž⁶, Miše BP⁷, Dabelić N⁸, Vazdar L⁹, Vrdoljak E¹⁰.

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Abstract

OBJECTIVES:

Randomized trials involving aromatase inhibitors (AIs) in the adjuvant treatment of breast cancer patients have reported increased osteoporosis risk. Bone loss can be reduced with appropriate life style, vitamin D and calcium supplements, and with bisphosphonate therapy. The aim of this analysis was to investigate adherence to vitamin D and calcium in postmenopausal breast cancer patients receiving adjuvant non-steroidal AIs, and oncologists' adherence to the bone health guidelines.

MATERIAL AND METHODS:

This prospective study included 438 newly diagnosed patients and those who have already been receiving non-steroidal AIs for up to 3.5 years. Median endocrine therapy duration before recruitment in the study was 10.5 months (interquartile 4.8-26.6).

RESULTS:

Densitometry was performed on 142 patients (32.4%) before initiation of endocrine therapy, and on additional 38 (8.6%) patients at second study visit. Densitometry was not performed on 258 (59%) patients. Vitamin D and calcium were prescribed to 329/438 (75.1%) patients at some point during the study. Patients who took more than 80% of the prescribed dose were considered adherent. Self-reported adherence was 88.4%. Osteoporosis was diagnosed in 24 patients (5.5%) of the total study population, bearing in mind that 258/438 (59%) patients did not have densitometry. Bisphosphonates were prescribed to 54/438 (12.3%) patients, whilst only 19 (35.2%) of those had osteoporosis.

CONCLUSION:

In this analysis, lack of oncologists' adherence to the bone health guidelines was observed. In addition, a significant proportion of the patients did not adhere to the vitamin D and calcium.

KEYWORDS:Aromatase inhibitors; Bone health; Breast cancer; Calcium; Vitamin D

PMID: 27810693  DOI: 10.1016/j.breast.2016.10.018

資料來源：PubMed
連結網址：https://www.ncbi.nlm.nih.gov/pubmed/27810693