Am J Obstet Gynecol. 2016 Jul 26. pii: S0002-9378(16)30521-X. doi: 10.1016/j.ajog.2016.07.048.

Author
Scherzer R¹, Greenblatt RM², Merhi ZO³, Kassaye S⁴, Lambert-Messerlian G⁵, Maki PM⁶, Murphy K⁷, Karim R⁸, Bacchetti P⁹

Author information
 

• ¹Department of Medicine, University of California, San Francisco, San Francisco, CA; San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA.
• ²Department of Medicine, University of California, San Francisco, San Francisco, CA; Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA. Electronic address: ruth.greenblatt@ucsf.edu.
• ³Department of Obstetrics and Gynecology, Division of Reproductive Biology, New York University School of Medicine, New York, NY.
• ⁴Department of Infectious Diseases, Georgetown University Medical Center, Washington, DC.
• ⁵Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Providence, RI.
• ⁶Departments of Psychiatry and Psychology, College of Medicine, University of Illinois at Chicago, Chicago, IL.
• ⁷Department of Medicine, Albert Einstein College of Medicine, Bronx, NY.
• ⁸University of Southern California, Los Angeles, CA.
• ⁹Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.

Abstract

BACKGROUND:

HIV infection has been associated with early menopausal onset, which may have adverse long-term health consequences. Antimüllerian hormone, a biomarker of ovarian reserve and gonadal aging, is reduced in HIV-infected women.

OBJECTIVE:

We sought to assess the relationship of antimüllerian hormone to age of menopause onset in HIV-infected women.

STUDY DESIGN:

We used antimüllerian hormone levels measured in plasma in 2461 HIV-infected participants from the Women's Interagency HIV Study to model the age at final menstrual period. Multivariable normal mixture models for censored data were used to identify factors associated with age at final menstrual period.

RESULTS:

Higher antimüllerian hormone at age 40 years was associated with later age at final menstrual period, even after multivariable adjustment for smoking, CD4 cell count, plasma HIV RNA, hepatitis C infection, and history of clinical AIDS. Each doubling of antimüllerian hormone was associated with a 1.5-year increase in the age at final menstrual period. Median age at final menstrual period ranged from 45 years for those in the 10th percentile of antimüllerian hormone to 52 years for those in the 90th percentile. Other factors independently associated with earlier age at final menstrual period included smoking, hepatitis C infection, higher HIV RNA levels, and history of clinical AIDS.

CONCLUSION:

Antimüllerian hormone is highly predictive of age at final menstrual period in HIV-infected women. Measuring antimüllerian hormone in HIV-infected women may enable clinicians to predict risk of early menopause, and potentially implement individualized treatment plans to prevent menopause-related comorbidities and to aid in interpretation of symptoms.

Copyright © 2016 Elsevier Inc. All rights reserved.

KEYWORDS:

AIDS; HIV; antimüllerian hormone; hepatitis C virus infection; menopause; ovarian reserve; viremia